Creatinine Clearance by Age — Normal Values & Calculator
See normal creatinine clearance ranges by age and calculate your estimated CrCl. Understand age-related kidney decline. Free calculator.
How Age Affects Creatinine Clearance
Kidney function naturally declines with age. After age 40, the glomerular filtration rate (GFR) and creatinine clearance (CrCl) decrease by approximately 1 mL/min per year. This is a normal physiological process unrelated to kidney disease.
Normal CrCl Ranges by Age (Male)
| Age Range | CrCl (mL/min) |
|---|---|
| 20–29 | 88–146 |
| 30–39 | 82–138 |
| 40–49 | 75–125 |
| 50–59 | 67–110 |
| 60–69 | 55–95 |
| 70+ | 45–80 |
Normal CrCl Ranges by Age (Female)
| Age Range | CrCl (mL/min) |
|---|---|
| 20–29 | 75–128 |
| 30–39 | 69–120 |
| 40–49 | 63–110 |
| 50–59 | 57–95 |
| 60–69 | 47–82 |
| 70+ | 38–68 |
Clinical Significance
Age-adjusted CrCl values are critical for appropriate medication dosing in elderly patients, who are at higher risk of drug accumulation and toxicity due to reduced renal clearance.
Frequently Asked Questions
Is a lower creatinine clearance in older adults always a sign of kidney disease?
Not necessarily. A gradual decline in CrCl with aging is normal. However, a CrCl below 60 mL/min at any age, or a rapid decline, warrants evaluation by a healthcare provider to rule out chronic kidney disease.
How often should older adults get creatinine clearance tested?
Adults over 60 with conditions such as diabetes, hypertension, or cardiovascular disease should have kidney function monitored at least annually. Those with existing CKD may need more frequent testing every 3–6 months.